Senior Medical Director

The Position At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a  Senior Medical Director  to join our Clinical Sciences team and take a central role in pioneering the future of healthcare.   As a  Senior  Medical Director,   you'll  be at the forefront of translating genetic insights into  innovative treatments for patients . Your work will  help drive the clinical development programs  for game-changing  therapies, starting with a  small molecule that targets  SLC6A19  – a  novel therapeutic target for the treatment of  chronic kidney disease  and phenylketonuria .     Maze Therapeutics has an exciting pipeline spanning both rare and common renal, cardiac, and metabolic diseases. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.    To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As a Senior Medical Director for one or more development programs, you will partner closely with cross-functional team members and other technical experts to design, conduct, and interpret the key clinical studies, including first-in-human and proof-of-concept trials. Your contributions will be highly visible and integral to the success of the Maze team.   This position reports to  the Head of Clinical  Development .   The Impact You’ll Have Lead the design, execution, and analysis of   clinical trials for  the  SLC6A19  program and other  early-stage  clinical   assets at Maze   Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs     Prepare and deliver scientific presentations  and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators.   Engage with scientific thought leaders and  patient advocacy groups   to  gain insights to inform clinical development plans and  build awareness and enthusiasm for the Maze pipeline assets .   Partner with Clinical Development Operations to  identify  and select study investigators and sites and  b uild strong professional relationships with study investigators.   Partner with Clinical Development Operations to  identify , select, and oversee vendors and CROs to support program needs .   Develop and integrate  timelines and budgets  for  clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders .   As a Senior Director , we also expect our leaders to demonstrate the following Leadership Competencies: Communication and Influence Builds communication channels across Maze for sharing information.   Influences Senior Management decisions through persuasive arguments.   Respectfully addresses differing opinions leading to support of decisions.   Teamwork and Collaboration Champions partnerships and connections across Maze.   Proactively addresses issues that could result in breakdown of team relationships.   Spotlights team and individual contributions in public forums.   Execution and Results Addresses gaps and leverages strengths to get  best  results.   Maintains a  steadying  presence and clarifies priorities during change.   Anticipates and removes barriers that put functional/corporate goals at risk.   Develop Others and Self Remove barriers to staff development and empowers them to make their own decisions.   Stays current on industry trends and keeps direct-reports prepared and responsive.   What We’re Looking For MD  with  6 + years  of  drug development  industry experience .     Board eligibility/certification and clinical experience  in internal medicine  and/or  pediatrics.  Additional  clinical or research experience in  nephrology  or cardiometabolic diseases is preferred.   E xperience  as a clinical study medical monitor    Experience with the preparation and submission of  scientific publications,  study protocols ,  Investigator Brochures , and other clinical-regulatory documents.     Experience in the  planning and oversight  of early-stage and/or registration-enabling clinical development programs including CRO  and site  selection and relationship building with investigators/site study staff,  patient  advocacy groups, and other third parties    Demonstrated knowledge and experience  in  the desig n and conduct of  clinical trials  and clinical data analysis and interpretation , particularly Phase 2 trials .   Experience leading a cross-functional study team.   Committed to nurturing relationships with  investigators, site study staff, patient advocacy groups, and other third parties  to support  the clinical programs and broader Maze objectives .      Exceptional  organizational, analytical,  and communication skills, enabling you to translate corporate  objectives  into actionable plans that consistently deliver high-quality data on time and within budget.   A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals.   Willingness to travel domestically and internationally  ( up to   20 %)  for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential  gatherings. ­   This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters at least three days per week.     About Maze Therapeutics Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule pro