Director, IT Enterprise Architect

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Director, Enterprise Architecture will establish Madrigal’s enterprise architecture capability as a practical strategy-to-execution function that connects business strategy and outcomes to the technology landscape using business capability language. This role will build and maintain an enterprise view of current and future-state capabilities, map platforms/data/integrations to those capabilities, and translate that into clear roadmaps and investment guidance so IT decisions are anchored in business outcomes. This is an execution-oriented architect who will define and implement the IT-wide architecture standards that do not exist today (principles, reference architectures, patterns, and minimum viable architectures) and operationalize them through lightweight governance and hands-on engagement with delivery teams. They will work directly with business and IT stakeholders at all levels to facilitate capability mapping workshops, resolve tradeoffs, and guide real design decisions in-flight, ensuring solutions are reusable, compliant, and scalable while still enabling speed. Key Responsibilities: Enterprise Standards, Guardrails & Architecture Governance Establish fit for purpose architecture governance (decision rights, review paths, exceptions) that enables speed while protecting security, compliance, and scalability. Orchestrate the creation, alignment, and rollout of IT-wide architecture standards and reference patterns with technical domain leads, ensuring consistent enterprise adoption. Drive a shared set of “minimum viable architecture” expectations for common solution types by aligning domain owners and ensuring consistent usage through checkpoints and exception handling. Ensure standards are operationalized through tooling, templates, and embedded engagement. Business Capability Architecture & Strategy Alignment Build and maintain Madrigal’s enterprise capability model and use it as the primary language for technology strategy, prioritization, and alignment. Map key platforms, data, and integrations to business capabilities to create clear line-of-sight from strategy to capability to technology decisions. Facilitate capability-based planning with business and IT leaders to identify gaps, redundancies, and investment priorities. Translate business strategy and operating needs into actionable architecture themes and roadmaps that guide delivery teams. Target Architecture, Roadmaps & Portfolio Modernization Curate a living enterprise architecture repository documenting the as-is and to-be landscape across applications, data, integrations, and technology platforms. Drive modernization and rationalization recommendations that reduce fragmentation and technical debt while enabling business outcomes. Partner with Strategy & Operations, Infra/Ops, and Data/AI leaders to align roadmaps and sequencing across domains. Provide architecture input into portfolio decisions (start/stop/sequence) by clarifying constraints, dependencies, and long-term impacts. Solution Enablement & Hands-On Delivery Partnership Engage directly with delivery teams to shape solution designs early, resolve tradeoffs, and prevent rework late in the lifecycle. Support high-priority initiatives as a working architect (workshops, design sessions, integration patterns, data flows), especially where the enterprise impacts are highest. Increase reuse by steering teams toward shared platforms, standard patterns, and approved building blocks. Partner with PMs and program leaders to ensure architecture decisions, risks, and exceptions are visible, decisioned, and tracked. Stakeholder Influence, Communication & Decision Support Serve as a trusted advisor to ITLT and business leaders by presenting clear options, implications, and tradeoffs in business language. Build alignment across functions by creating transparent, capability-led narratives for why technology decisions are being made. Drive decision velocity by proactively surfacing architectural risks, constraints, and needed choices before they become delivery blockers. Enable enterprise-wide architectural literacy through coaching, practical guidance, and consistent communication of standards and direction. Architecture Stewardship & Rationalization Stand up and embed an enterprise architecture governance model, including decision routes, review triggers, and exception management, ensuring consistent execution across domains. Maintain a central registry of architecture exceptions and technical debt, including owners and remediation expectations. Inform major platform and technology decisions by surfacing duplication, architectural inconsistencies, and consolidation opportunities across the IT landscape. Ensure solutions meet enterprise “ready for production” standards before go-live and escalate gaps early for decis