Director, US Commercial Enablement

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn  and Facebook . Role Summary   The Director, US Commercial Enablement drives strategic commercial enablement initiatives and builds foundational tools, processes, and capabilities to support business growth and launch readiness. The Director establishes and optimizes field enablement infrastructure, including incentive compensation, CRM platforms, and business intelligence tools, while ensuring alignment across cross-functional stakeholders. This role enhances field effectiveness, builds scalable processes, and promotes operational excellence with a patient-first mindset.   This position is based in Waltham, MA    Primary Responsibilities Include:   Incentive Compensation and Performance Programs   Leads planning, design, and administration of incentive compensation and bonus programs across commercial, medical, and patient services teams   Develops plan design models, manages payouts, and delivers monthly and quarterly reporting   Maintains plan documentation, tracking systems, and performance monitoring processes   Conducts regular performance reviews with stakeholders to optimize program effectiveness   Partners with field teams to build account planning tools   Leads recognition programs, including Circle of Excellence and associated planning   Commercial Systems, Tools, and Analytics   Serves as commercial business owner for CRM platforms (e.g., Veeva), translating field needs into system enhancements   Partners with IT and stakeholders to implement and optimize CRM and data solutions   Owns business intelligence reporting tools and ensures data accuracy through quality control processes   Supports reporting platforms across market access and patient services   Optimizes field enablement tools and materials to improve productivity and effectiveness   Field Operations and Infrastructure   Designs and implements fleet program aligned with business needs and industry benchmarks   Maintains and updates fleet policies in collaboration with Compliance, HR, Finance, and Field Leadership   Builds scalable processes to support field teams and commercial operations   Cross-Functional Planning and Execution   Leads coordination of national, regional, and headquarters meetings in partnership with Marketing and Commercial teams   Drives cross-functional planning across Sales, Marketing, Market Access, Advanced Analytics, Patient Services, Finance, and IT   Ensures alignment and readiness to support commercial launch and execution   Strengthens collaboration and communication across teams   Education and Skills Requirements:   Bachelor’s degree; advanced degree preferred   12+ years of experience in biotech, pharmaceutical, or life sciences industry, including field sales, sales leadership, field operations, or consulting experience supporting commercial organizations   Demonstrated experience supporting or leading launch readiness, ideally in rare disease, neuromuscular, neurodegenerative, or neurodevelopmental therapies   Strong leadership and project management experience, including managing vendors and scaling commercial infrastructure   Strategic mindset with ability to execute and deliver results   Experience with commercial technology platforms and data environments (e.g., CRM, BI tools, Snowflake, Boomi, SP/SIP, HUB data)   Strong analytical and problem-solving skills   Excellent written and verbal communication skills, including ability to present to senior leadership   Demonstrated ability to collaborate effectively across cross-functional stakeholders   #LI-Onsite MA Pay Range $188,000 — $235,000 USD   The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements.  Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.