Executive Director, Head of Biometrics, Infectious Disease

The Opportunity Are you an expert in biometrics, statistics, or statistical programming ready for a transformative leadership opportunity? Would you like to play a pivotal role in the development of potential medicines and vaccines addressing some of the greatest unmet medical needs in infectious diseases? The Infectious Disease unit was created to optimize AstraZeneca's portfolio of vaccines and antibodies for infectious diseases. We are committed to developing and implementing scientific advancements that build pandemic preparedness, protect against future health crises, and bring lasting immunity to people around the globe. As  Head of Biometrics for Infectious Disease , you will have a unique opportunity to further elevate the Infectious Disease Therapy Area in one of the world's most respected biopharmaceutical companies. You will be a core member of the  Late Infectious Disease Development Leadership Team , leading the global capability for biostatistics, statistical programming, and associated disciplines supporting the ID pipeline. Strategic Priorities ·    Drive Quantitative Strategy:  Serve as the overall accountable leader for the strategy and execution of quantitative analytics across all Clinical Development Programs (CDPs) within the Infectious Disease Therapeutic Area. ·     Champion Statistical Innovation:  Push the boundaries of modern statistical methods—including innovative trial design, digital sensor data analysis, and AI-enabled approaches—through collaboration, publication, and scientific exchange with external academic and industry groups. ·      Build and Grow World-Class Talent:  Attract, retain, and develop a high-performing, cross-skilled team of statisticians, programmers, and associated disciplines, creating a stimulating environment that allows team members to grow their careers in multiple directions. ·       Strengthen External Influence:  Maintain a wide set of collaborative relationships with academics, KOLs, regulators, and cross-industry groups to enhance AstraZeneca's external standing and bring new ideas in-house. Key Accountabilities Leadership & Team Development ·        Lead and develop a cross-skilled team of statisticians, programmers, and other relevant disciplines—including individual contributors and team leaders—within a matrix environment. Ensure resource and expertise are appropriately deployed for maximal impact across multiple programmes. Drive programmes to maintain a high-quality, cutting-edge skills base aligned to R&D needs through permanent recruitment, outsourcing alliances, academic collaborations, graduate recruitment, internships, and secondments. Scientific & Technical Excellence ·        Ensure appropriate statistical designs, data collection and analysis tools, and processes to clearly and robustly address the objectives of clinical studies and programmes. Provide oversight for the quality and timeliness of clinical development planning, study design, analysis, and reporting—including contributions to study protocols, statistical analysis plans, clinical study reports, and regulatory activities. Influence decision-making for early/late clinical development plans, decision criteria, proof-of-concept study design, and in-licensing opportunities—specifically accountable for  quantifying uncertainty at investment decisions . Establish mechanisms for review of emerging real-time data during clinical trials and advances in statistical methodology for payer/reimbursement applications. Cross-Functional Collaboration & Governance ·        Represent the Biometrics function on the Late ID Development Leadership Team, contributing to strategy, vision, and objectives. Establish dynamic collaboration with other relevant groups to ensure smooth transition of clinical projects through each clinical phase. Collaborate with Biometrics Therapy Area Leaders and Clinical Teams to ensure statistical innovation across all development phases. Proactively direct strategic cross-R&D collaborations and represent AstraZeneca on internal/external panels, boards, and other bodies as required. Regulatory & External Engagement ·        Lead statistical contributions to global regulatory submissions and interactions with major Health Authorities (FDA, EMA, and others). Ensure a judicious review of innovative proposals so that the benefit/risk equation is well understood. Provide internal and external scientific, technological, and computational expertise to enhance evidence-based and data-driven clinical decision-making across R&D. Essential Qualifications & Experience ·          PhD  in Biostatistics, Applied Mathematics, Statistics, or other relevant quantitative discipline (MSc considered with exceptional experience), with a  minimum of 5 years  of pharmaceutical/life sciences industry experience. Demonstrated expertise in multiple statistical modalities across  Phase I–IV clinical trials , with a comprehensive understanding of the R&D drug development lifecycle. Substantial experience providing statistical and programming support to clinical development projects via direct report or matrix structure—including delivery of multiple complex, large studies (e.g., pivotal Phase 3 efficacy studies) in parallel. Experience with innovative statistical methods and fluency in regulatory language associated with statistical analysis plans. Experience with  global regulatory submissions  and interactions with major Health Authorities. Experience presenting to FDA Advisory Committees is a plus. Understanding of regulatory guidelines pertaining to data handling, integrity, and industry data standards (e.g., CDISC). Leadership/participation in cross-industry statistical subject-knowledge groups, with a demonstrable network of external experts. Essential Skills & Attributes   Strategic Leadership:  Proven ability to drive strategy in a pharmaceutical development environment, working collaboratively with cross-functi