Executive Medical Director, Medical Strategy (Hepatologist)

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Executive Medical Director, Medical Strategy (hepatologist), is a key member of the Medical Affairs global team and serves as Madrigal’s clinical and medical expert in Metabolic Dysfunction–Associated Steatohepatitis (MASH). This hepatology/liver expert will bring deep clinical and industry expertise to guide strategic direction and serve as a trusted advisor across the organization. In this role, the Exec Med Dir will partner closely with teams across Medical Affairs—including both field and headquarters functions in the U.S. and globally—to ensure scientific and medical alignment. The individual will also collaborate extensively with Clinical Development, Regulatory Affairs, Commercial, and Market Access to support cross-functional decision-making and integrated execution. Working in close partnership with the Vice President, Global Medical Affairs Strategy, the Exec Med Dir will help inform and help shape the company’s medical strategy for resmetirom and future assets. As a core member of the Medical Product Team (MPT), the Exec Med Dir will contribute to critical product and portfolio decisions that inform the strategic direction of Madrigal’s medical and scientific initiatives. The position will report to VP, Global Medical Affairs Strategy and is hybrid from the Conshohocken, PA or Waltham, MA offices (3 days a week in person). All incumbents are responsible for following applicable Division & Madrigal policies and procedures. Key Responsibilities · Strategic and Scientific Leadership o Serve as a senior Hepatology clinical and scientific subject-matter expert in MASH and related metabolic liver diseases, providing authoritative medical guidance to internal and external stakeholders. Inform and help shape global medical strategies by contributing deep clinical insight and scientific interpretation within the strategic framework established by Global Medical Strategy leadership. Partner with senior leaders across Global Medical Affairs, R&D, and HEOR to identify critical evidence gaps and drive meaningful data generation o Act as a senior medical advisor to Commercial and Market Access teams, providing scientific guidance on initiatives requiring medical expertise, in compliance with all regulations. Build and maintain relationships with top thought leaders (TLs), partnering with MSLs to manage strategic engagements and scientific collaborations o Participate in Corporate Advisory Panels ensuring strategic alignment with company-wide initiatives · Medical Affairs Research and Evidence Generation o Provide senior medical expertise and strategic input for Phase 4 and post-approval studies, in collaboration with Clinical Development leadership o Serve as a key medical advisor to HEOR, ensuring scientific relevance and credibility o Collaborate with HEOR and Clinical Development to define and execute a prioritized real-world evidence agenda o Serve as a core member of the Publication Strategy Review Team (PSRT) to ensure scientific integrity and medical accuracy o Support execution of the global Investigator-Initiated Study (IIS) strategy and governance processes, providing medical review and strategic input as requested. · Cross-Functional and Operational Integration o Serve as a senior Medical Affairs representative on the Medical Product Team (MPT), contributing clinical and scientific expertise to asset-level decision-makingAct as a primary medical partner to cross-functional program teams, ensuring medical strategy is appropriately integrated into program planning and execution. Provide strategic and scientific review for content, ensuring medical accuracy and relevance across materials and channels o Review and provide input on Custom and Standard Response Medical Information documents, ensuring consistency with the latest scientific evidence. o Serve as an advisor to the Medical Regulatory Committee (MRC), contributing to scientifically sound review processes o Work closely with Medical Strategy to plan and conduct advisory boards, ensuring scientific rigor and strategic value o Engage as a strategic advisor or member of the Brand Team, providing input into brand strategy and ensuring scientific alignment. · Field Medical and Scientific Excellence o Contribute to the training of field medical teams to ensure scientific accuracy and consistency o Provide clinical mentorship and continuous development to enhance scientific acumen and engagement capabilities · Organizational Leadership and Talent Development o Foster a culture of scientific excellence, collaboration, and continuous improvement within Global Medical Affairs · Compliance & Quality o Ensure all activities comply with company SOPs, industry standards, and applicable regulations o Uphold the highest ethical standards in all external engagements · Travel Requirement o Ability