Principal Software Engineer

Career Category Information Systems Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Software Engineer, Information Systems What you will do Let’s do this. Let’s change the world. In this vital role, you will lead the architecture, design, and development of modern, enterprise-grade user interfaces that support Contracting, Pricing, and Commercial Operations business processes. You will leverage React, TypeScript, and contemporary frontend technologies to build intuitive, responsive, and highly interactive applications that deliver exceptional user experiences while adhering to enterprise standards for scalability, accessibility, security, and maintainability. The primary objective of this role is to drive UI innovation and digital transformation by partnering closely with business stakeholders, product teams, and engineers to translate complex business requirements into elegant user-centric solutions. You will define frontend architecture, establish reusable design patterns and component frameworks, integrate AI-powered experiences and enterprise platforms, and lead the delivery of scalable applications that improve productivity, streamline workflows, and accelerate business outcomes. This role requires hands-on involvement in solution design, prototyping, and implementation.  Lead architecture, design, and delivery of enterprise web applications using modern frontend and backend technologies. Develop highly interactive user experiences using React, TypeScript, Next.js, and modern frontend frameworks. Define and evolve enterprise frontend architecture, design systems, reusable component libraries, and UI engineering standards to ensure consistency, scalability, accessibility, and exceptional user experiences across applications. Design and implement AI-powered applications leveraging Generative AI, Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), and agentic architectures. Build intelligent assistants, copilots, and conversational interfaces for Contracting, Pricing, and Commercial Operations users. Design and implement scalable API-driven, event-based, and integration architectures across enterprise platforms including Salesforce, Conga CLM/CPQ, Model N, Anaplan, Databricks, MuleSoft, and other business systems. Partner with business stakeholders to identify opportunities for automation, AI enablement, workflow optimization, and digital transformation. Lead rapid prototyping and proof-of-concept initiatives to validate emerging technologies, AI capabilities, and business use cases. Lead adoption of modern DevOps practices including CI/CD automation, infrastructure as code, application monitoring, observability, and cloud-native deployment strategies. Leverage AI-assisted software development tools and emerging engineering platforms to accelerate prototyping, application delivery, code quality, and developer productivity. Establish architecture standards and engineering best practices for frontend development, AI-powered applications, DevOps, security, scalability, observability, and software delivery. Provide technical leadership and mentorship across engineering teams, driving architecture governance, engineering excellence, DevOps maturity, and adoption of modern development and AI-enabled engineering practices. Technology Focus Areas Full-stack application development using React.js, Next.js, TypeScript, Node.js, and Python. Modern frontend architecture, responsive user experience design, and component-based application development. Backend API development, microservices architecture, and scalable enterprise application design. Generative AI and Large Language Models (LLMs) applied to business workflows and productivity solutions. Retrieval Augmented Generation (RAG) architectures leveraging enterprise data sources and knowledge repositories. AI copilots, assistants, and agent-based applications embedded within enterprise platforms. Prompt engineering, orchestration frameworks, and AI application lifecycle management. Integration with enterprise AI platforms such as Azure OpenAI, OpenAI, Anthropic, Gemini, or similar services. Cloud-native application development and deployment using Azure and related cloud services. DevOps practices including CI/CD pipelines, GitHub Actions, Azure DevOps, Infrastructure as Code, and automated testing. Containerization and orchestration technologies including Docker and Kubernetes. Enterprise SaaS platforms including Salesforce, Conga CLM and CPQ, Model N, MuleSoft, Databricks, and Anaplan. System integration patterns including APIs, microservices, event-driven architectures, and data synchronization. Workflow automation, orchestration, and business process optimization across contracting, pricing, and revenue management processes. Data engineering, analytics integration, and enterprise data platfor