Sr. Scientist, Radiopharmaceutical Development

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/ Summary RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals The Sr. Scientist, Radiopharmaceutical Development is a leading contributor in the design, development, and advancement of RayzeBio’s radiopharmaceutical programs. This senior role is responsible for translating cutting-edge scientific discoveries into robust clinical drug products and driving technology transfers. The Sr. Scientist will lead CMC radiopharmaceutical process development, oversee IND-enabling activities, and play a pivotal role in clinical manufacturing. This position demands expertise in radiochemical synthesis, analytical techniques, and radiopharmaceutical formulation, as well as a proven ability to manage complex projects and mentor junior staff. Job Responsibilities Essential duties and responsibilities include the following. Other duties may be assigned. Process Development & Scale-Up: Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards. Technology Transfer: Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites, including the Indianapolis facility and CDMO partners. Laboratory Oversight: Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure, ensuring readiness for translational activities from preclinical through clinical phases. Collaboration: Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs to address complex scientific questions and pursue joint research efforts. Lead Research Initiatives: Independently design and execute advanced radiochemistry and radiolabeling experiments, with a special focus on novel radioisotope and chelator development to enable new classes of radiopharmaceuticals. Technical Leadership: Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies. Provide scientific leadership across multidisciplinary teams. Safety & Compliance: Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials; promote a culture of safety-first and regulatory compliance. Data Analysis & Reporting: Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders. Project Management & Mentorship: Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates. Documentation: Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports. Travel: Less than 10% travel required, including external research sites and manufacturing facilities. Education and Experience BSc +7, MSc + 5 years or PhD 2 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience, including significant CMC work with radiopharmaceutical products. Experience in radiopharmaceutical companies leading technology transfers to internal manufacturing or external CDMO partners for Phase 1 clinical programs strongly preferred. Demonstrated expertise in radiochemical synthesis, purification, formulation, and analytical techniques. Proven track record of innovation in radiopharmaceutical development. Deep familiarity with federal and state regulatory requirements and safety protocols for radioactive materials. Skills and Qualifications Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution. Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy. Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications. Strong professional ethics, integrity, and ability to maintain confidential information. Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership. Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment. Demonstrated ability to manage complex research projects and mentor junior staff. Physical Demands While performing duties, the employee is regularly required to sit, reach with hands and arms, and talk or hear. Occasional lifting and/or moving up to 30 pounds may be required. Spe