Vice President, Translational Medicine & Clinical Biomarkers

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Nurix Therapeutics is seeking an accomplished scientific leader to serve as Vice President, Translational Medicine & Clinical Biomarkers. This executive will own the full translational medicine and clinical biomarker strategy across Nurix’s oncology and immunology pipeline, from early target engagement through late-stage clinical development and will serve as a decisive voice in portfolio-level go/no-go decisions. Reporting to the Chief Scientific Officer, the VP will lead and scale a high-performing team, partner closely with  Research, Clinical Development, Regulatory Affairs, and Data Science, and represent Nurix externally as a  scientific leader in translational medicine. This role carries executive accountability for the translational  medicine function, including CRO and diagnostic partner strategy, and requires the rare combination of deep  scientific expertise, operational fluency, and the leadership presence to influence at the executive level. This is a senior executive role for a builder. Someone who has led translational functions through clinical  inflection points and can define what precision medicine looks like at a biotech pioneering targeted protein  degradation. Responsibilities Strategic Leadership & Portfolio Ownership Define and own the enterprise-wide translational medicine and clinical biomarker strategy across Nurix’s  pipeline, integrating insights from discovery through Phase II/III to inform portfolio prioritization and  investment decisions. Design and implement  predictive biomarker strategies  and translational plans to support indication selection and patient enrichment for degrader therapies . Serve as a standing member of the R&D leadership team and program governance committees; provide executive-level input on clinical development strategy, indication selection, dose/schedule decisions, and precision medicine positioning. Translate the unique biology of targeted protein degradation into rigorous translational hypotheses, from  degrader-specific target engagement biomarkers to modality-specific patient stratification strategies. Represent Nurix in external scientific forums, KOL engagements, investigator meetings, and competitive  intelligence activities; contribute to business development diligence on potential partnerships and in-licensing candidates. Translational Science & Biomarker Development Oversee the full lifecycle of biomarker program development, from preclinical discovery and assay feasibility through clinical validation, implementation, and reporting. Ensure scientific rigor and regulatory  defensibility at each stage. Direct design and execution of pharmacodynamic, predictive, prognostic, and safety biomarker strategies for each program; establish clear criteria for biomarker-driven decision gates. Integrate advanced translational data modalities, ctDNA/ctRNA, single-cell sequencing, spatial transcriptomics, computational pathology, and multiplex imaging into Nurix’s precision medicine  Partner with Discovery Biology to build translationally anchored preclinical models and IND-enabling data  packages that de-risk clinical hypotheses. Lead clinical biomarker data interpretation and synthesis across programs; translate complex datasets into actionable insights for clinical teams, executives, and regulatory agencies. Clinical Integration & Regulatory Partnership Provide scientific leadership for translational and biomarker content in clinical protocols, Investigator Brochures, clinical study reports, and regulatory submissions (INDs, BLAs, briefing documents). Shape biomarker regulatory strategy in close collaboration with Regulatory Affairs; represent translational science in FDA and EMA interactions, including pre-IND and End-of-Phase meetings. Partner with Clinical Pharmacology on integrated PK/PD modeling, dose-response biomarker analysis, and  mechanism-based endpoint selection. Collaborate with Biostatistics and Data Science on statistical analysis plans, integrated translational datasets, and exploratory analyses that support publication and regulatory strategy. Provide leadership in companion diagnostic (CDx) strategy, including CRO/IVD partner selection and regulatory co-development planning where applicable. Operational Excellence & External Partnerships Define and manage the translational medicine operating model, including infrastructure, technology platforms, and quality standards appropriate to Nurix’s stage and pipeline breadth. Evaluate, select, and govern CRO, central laboratory, and academic collaborative partnerships for biomarker assay development and clinical execution; ensure scientific and contractual accountability. Develop and manage the translational medicine budget and resource allocation; provide forward-looking investment guidance aligned with clinical timelines and portfolio priorities. Team Leadership & Organizational Development Build, inspire, and develop a high-performing team of translational scientists and biomarker specialists; set clear goals, cultivate scientific rigor, and support career growth. Define team structure, roles, and growth pathways appropriate to Nurix’s pipeline stage; attract and retain top-tier scie