VP, U.S. Medical Affairs

Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn  and Facebook . Role Summary: The VP, U . S .  Medical Affairs is  the senior U.S.   medical leader with  end-to-end   accountability for U.S. medical launch readiness, execution, and early commercialization success for Dyne’s first approved product. This role  will continue to build ,  lead , and scale  a high-impact U.S .  Medical Affairs organization  and serve as a critical leader  capable of delivering excellence in a first-launch,  high ‑ visibility  environment.   This position plays a critical leadership role in shaping Dyne’s transition from a clinical-stage to a commercial-stage company, serving as a core member of cross-functional launch governance and a  trusted strategic advisor  to  e xecutive  l eadership  and member of the US Leadership Team (USLT) . The VP is accountable for defining and executing the U.S. medical strategy, ensuring scientific and medical excellence, mitigating medical risk, and driving impactful engagement with U.S. healthcare providers, payers, patient communities, and other external stakeholders.   The VP, U . S .  Medical Affairs is a key member of the Global Medical Affairs Leadership Team and works in close collaboration with Global Medical Affairs, Commercial, Market Access, Clinical Development, Regulatory, and other functions to ensure seamless alignment and execution through approval, launch, and early lifecycle management.   This is a unique opportunity to define and lead the U.S. medical strategy for Dyne’s first commercial product and  establish  the foundation for future launches in a rapidly evolving rare disease portfolio.   This role is based in Waltham, MA.   Primary Responsibilities  Include :   Deliver a highly effective U.S. medical launch that enables appropriate, evidence-based adoption    Establish a credible and trusted Dyne scientific presence with U.S. KOLs, payers, and patient communities    Build a scalable, high-performing Medical Affairs organization ready for multiple launches    Effectively translate scientific and clinical data into strategies that drive both access and lifecycle value   E stablish foundational capabilities and ways of working in a first-launch environment      Enterprise & Launch Leadership   Own U.S. medical strategy, launch readiness, and execution, with direct accountability for delivering  multiple successful product launches from a medical affairs perspective   Build and develop a strong leadership bench, establishing a leadership team capable of scaling with the organization and future launches   Serve as a core member of cross-functional launch leadership, shaping enterprise decisions  and influencing cross-functional tradeoffs, while  resolving complex scientific, medical, and operational balance in a time-critical environment   Ensure U.S. Medical Affairs capabilities, processes, governance, and resourcing are built and operationalized to support launch and early commercialization   Represent U.S. Medical Affairs scientific priorities and business needs at the US LT and the GMA LT   Drive culture intentionally during scale   U.S. Medical Affairs Strategy & Execution   Define, own, and execute the U.S. Medical Affairs strategy aligned with global medical strategy and enterprise objectives   Ensure aligned cross-functional strategies, goals, and execution in partnership with US LT   Translate medical and clinical insights into actionable strategies that support appropriate product adoption, evidence generation, payer confidence, and long-term lifecycle value   Oversee U.S. medical tactics, including KOL strategy, advisory boards, congresses, medical education, payer engagement, and scientific exchange   Organization Building & People Leadership   Build, lead, and scale a best-in-class U.S. Medical Affairs organization, including Field Medical (Medical Science Liaisons and Medical Value Liaisons) and home-office medical functions, capable of operating with speed, rigor, and scientific credibility while delivering high impact outcomes in a first-launch setting and preparing for subsequent launches   Establish clear goals, decision rights, accountability, and performance expectations across the organization   Develop leadership bench strength, foster a culture of ownership and collaboration, and act as a role model for Dyne’s values during a period of rapid organizational growth   Ensure comprehensive training and learning programs to continuously develop a high performing U.S. Medical Affairs organization   External Engagement & Scientific Leadership   Serve as Dyne’s senior U.S. medical spokesperson to key external stakeholders, including clinical experts, academic leaders, payers, advocacy groups, and other partners   Shape and optimize treatment paradigms through credible, compliant, and impactful scientific engagement   Ensure high-quality, fair-balanced medical and scientific exchange across all U.S. external interactions   Ensure real-time intelligence on competitive data and evolving treatment paradigm   Evidence Generation & Lifecycle Management   Provide strategic oversight of U.S.-focused evidence generation, ensuring alignment with launch and lifecycle priorities   Lead cross-functional alignment with Global Medical Affair